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    當前位置 > 首頁 > 新聞動態 > 科技前沿
    草莓和石榴中的特殊代謝產物或能有效抑制炎性腸病的進展
    更新日期: 2019-01-28 作者: Rajbir Singh等 文章來源:《自然通訊》
    打印 文本大小:    

     

     

    近日,一項刊登在國際雜志Nature Communications上的研究報告中,來自路易斯維爾大學通過研究發現,草莓和石榴中一種名為尿石素AUrolithin AUroA)的微生物代謝產物或能幫助降低并保護機體抵御炎性腸病(IBD),如今全球有數百萬人遭受炎性腸病(比如克羅恩病等)的折磨,但并沒有有效的療法對其進行治療。

    這項研究中,研究者通過對動物模型進行研究發現,UroA及其合成相似物UAS03能夠通過增加加強腸道上皮細胞連接的蛋白質并減少腸道炎癥的方式,來減緩炎性腸病的進展;腸道屏障的緊密連接能夠抑制不合適微生物及毒素的入侵,進而有效預防炎性腸病的發生。研究者指出,UroAUAS03不僅能夠減緩炎癥表現,還能恢復腸道屏障的完整性,保護機體抵御結腸炎的發生。

    研究者Rajbir Singh博士說道,目前為止,科學家們認為,尿石素能通過抗炎和抗氧化的特性來產生有益效應,這項研究中我們首次發現,這種功能模式包括修復腸道屏障的異常并維持腸道屏障的完整性。此外,研究者還闡明了人類機體微生物群落所產生的代謝產物影響機體多個方面的分子機制,通過理解特殊代謝產物的效應,研究者就希望利用能夠開發出治療炎性腸病等多種疾病的新型療法。

    腸道中的假鏈狀雙歧桿菌INIA P815能通過鞣花酸(EA)來制造UroA,鞣花酸是草莓和石榴中的一種特殊化合物,研究者認為,利用較為穩定的合成性UAS03或許就能有效治療急性結腸炎,當然后期還需要進行更多試驗和臨床檢測來證實這種想法。研究者Jala說道,腸道中的微生物能夠進化到在腸道屏障附近產生有意的代謝產物,這就需要我們攝入較為健康的飲食。

    本文研究結果表明,直接攝入UroA或其類似物或許就能補償機體中產生UroA的特殊細菌的缺失,同時持續攝入草莓和石榴也能夠帶來類似的保護效應,最后研究者表示,UroAUAS03具有一定的治療性和保護性效益,其能有效逆轉結腸炎患者的癥狀,幫助改善患者的生活質量。(來源:生物谷Bioon.com

     

    Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

     

    Abstract  The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in human health and disease remain elusive. Urolithin A (UroA), a major microbial metabolite derived from polyphenolics of berries and pomegranate fruits displays anti-inflammatory, anti-oxidative, and anti-ageing activities. Here, we show that UroA and its potent synthetic analogue (UAS03) significantly enhance gut barrier function and inhibit unwarranted inflammation. We demonstrate that UroA and UAS03 exert their barrier functions through activation of aryl hydrocarbon receptor (AhR)- nuclear factor erythroid 2–related factor 2 (Nrf2)-dependent pathways to upregulate epithelial tight junction proteins. Importantly, treatment with these compounds attenuated colitis in pre-clinical models by remedying barrier dysfunction in addition to anti-inflammatory activities. Cumulatively, the results highlight how microbial metabolites provide two-pronged beneficial activities at gut epithelium by enhancing barrier functions and reducing inflammation to protect from colonic diseases.

     

    原文鏈接:https://www.nature.com/articles/s41467-018-07859-7

     


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